Pub. Date : 1998 May
PMID : 9635876
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | E1 metabolism to 16alpha-OHE1 in a panel of 15 human liver microsomal preparations correlated with total P450 concentrations (r2 = 0.63) and with activities associated with P450 forms CYP3A4 and 3A5 (r2 = 0.72). | 16-hydroxyestrone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Microsomal preparations of cDNA expressed CYP3A4 or 3A5, with NADPH-P450-reductase co-expressed, both metabolized E1 to 16alpha-OHE1, and added cytochrome b5 increased the rates 5.1- and 7.5-fold, respectively. | 16-hydroxyestrone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |