Pub. Date : 1997
PMID : 9633822
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fibroblast growth factor-2 and TPA enhance prostate-cancer-cell proliferation and activate members of the Ras and PKC signal transduction pathways. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 2 | By contrast, TPA promoted rapid activation of all three PKC isozymes. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 3 | Both the TPA- and FGF-2-mediated PKC activation were prolonged and possibly involved cyclic redistribution of isozymes between soluble and particulate cell fractions. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 4 | The results of these studies indicate that FGF-2 and TPA independently and conjointly modulate rat prostate-cancer-cell antisense-transfectant doubling time and suggest that effector modulation of rat prostate-cancer-cell proliferation is achieved by processes involving PKC and/or ras mediated signaling. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |