Title : RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding.

Pub. Date : 1998 Jul

PMID : 9632785






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 U2AF binds site specifically to the intron pyrimidine tract between the branchpoint and the 3" splice site and targets U2 snRNP to the branch site at an early step in spliceosome assembly. pyrimidine U2 small nuclear riboprotein auxiliary factor 38 Drosophila melanogaster
2 The site-specific pyrimidine tract binding activity of the U2AF heterodimer has previously been assigned to hU2AF65. pyrimidine U2 small nuclear riboprotein auxiliary factor 38 Drosophila melanogaster
3 When the Drosophila small-subunit homolog (dU2AF38) was complexed with the large-subunit (dU2AF50) pyrimidine tract, RNA binding activity increased 20-fold over that of free dU2AF50. pyrimidine U2 small nuclear riboprotein auxiliary factor 38 Drosophila melanogaster