Title : Cells of the neuronal lineage play a major role in the generation of amyloid precursor fragments in gelsolin-related amyloidosis.

Pub. Date : 1998 Jun 26

PMID : 9632693






1 Functional Relationships(s)
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1 Here, we provide evidence that this abnormal processing results from defective initial folding of the secreted FAF gelsolin due to the lack of the Cys188-Cys201 disulfide bond, normally formed next to the FAF mutation site. Disulfides gelsolin Homo sapiens