Pub. Date : 1998 Jun 18
PMID : 9632372
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | As a result of optimization of the combination with the N-alkyl group (R) and N-aryl group (Ar3), compound 3aq (FR186054) was identified as a new, orally efficacious ACAT inhibitor, which exhibited potent in vitro ACAT inhibitory activity (rabbit intestinal microsomes IC50 = 99 nM) and excellent hypocholesterolemic effects in cholesterol-fed rats, irrespective of administration mode (ED50 = 0.046 mg/kg dosed via the diet, ED50 = 0. | Cholesterol | sterol O-acyltransferase 1 | Oryctolagus cuniculus |