Title : Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner.

Pub. Date : 1998 May

PMID : 9630454






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phenobarbital (PB)-mediated induction of five forms of cytochrome P450 (CYP2B1, CYP2B2, CYP3A1, CYP2A1, and CYP2C6) and epoxide hydrolase is highly suppressed, at the transcriptional level, in Wistar Furth (WF) relative to Fischer 344 (F344) female rats. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus
2 Phenobarbital (PB)-mediated induction of five forms of cytochrome P450 (CYP2B1, CYP2B2, CYP3A1, CYP2A1, and CYP2C6) and epoxide hydrolase is highly suppressed, at the transcriptional level, in Wistar Furth (WF) relative to Fischer 344 (F344) female rats. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus
3 The LFD suppressed PB-induction of CYP mRNA and protein in WF but not F344 rats. Phenobarbital cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus