Pub. Date : 1998 Apr
PMID : 9630010
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 2 | FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 3 | Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 4 | Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 5 | Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 6 | Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |
| 7 | It is hypothesized that the interaction between the two drugs relies on a mechanism involving both competition of FK506 and CsA for CYP3A and of their immunophilin complexes for a common site on the calcineurin-calmodulin complex. | Tacrolimus | cytochrome P450, family 3, subfamily a, polypeptide 62 | Rattus norvegicus |