Title : FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction.

Pub. Date : 1998 Apr

PMID : 9630010






7 Functional Relationships(s)
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1 FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
2 FK506 (Tacrolimus) decreases the cytotoxicity of cyclosporin A in rat hepatocytes in primary culture: implication of CYP3A induction. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
3 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
4 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
5 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
6 Tacrolimus (FK506) and cyclosporin A (CsA) are two potent immunosuppressants mainly metabolized by hepatic cytochrome P-450 3A (CYP3A) monooxygenase. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
7 It is hypothesized that the interaction between the two drugs relies on a mechanism involving both competition of FK506 and CsA for CYP3A and of their immunophilin complexes for a common site on the calcineurin-calmodulin complex. Tacrolimus cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus