Title : Specific and irreversible cyclopeptide inhibitors of dipeptidyl peptidase IV activity of the T-cell activation antigen CD26.

Pub. Date : 1998 Jun 4

PMID : 9622551






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes. Proline dipeptidyl peptidase 4 Homo sapiens
2 The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes. Proline dipeptidyl peptidase 4 Homo sapiens
3 The dipeptidyl peptidase IV (DPP IV) activity of CD26 is characterized by its post-proline-cleaving capacity that plays an important but not yet understood role in biological processes. Proline dipeptidyl peptidase 4 Homo sapiens
4 Taking into account the substrate specificity of DPP IV for P2-P1><-P1" cleavage, we have designed and synthesized cyclopeptides c[(alphaH2N+)-Lys-Pro-Aba-(6-CH2-S+R2)-Glyn] 2TFA- (Aba = 3-aminobenzoic acid, R = alkyl) possessing a proline at the P1 position and a lysine in the P2 position, which allows the closing of the cycle on its side chain. Proline dipeptidyl peptidase 4 Homo sapiens