Title : Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism.

Pub. Date : 1998 Jun 1

PMID : 9622076






2 Functional Relationships(s)
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1 This study indicates that CYP1B1 is an important activator of polycyclic aromatic hydrocarbons in the mammary gland when environmental chemical exposures minimally induce CYP1A1. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 Additionally, certain individuals express low levels of basal CYP1A1 in HMECs, representing a potential risk factor of mammary carcinogenesis through enhanced polycyclic aromatic hydrocarbon bioactivation. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily A member 1 Homo sapiens