Title : Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma.

Pub. Date : 1998

PMID : 9621513






1 Functional Relationships(s)
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1 A mutation at codon 918, causing the substitution of threonine for methionine in the tyrosine kinase domain of the protein, was found in germline DNAs of all four patients with MEN2B and in two of the 22 patients with sporadic MTCs; codon 918 was mutated somatically in tumor DNAs from three other sporadic cases. Threonine ret proto-oncogene Homo sapiens