Title : Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain.

Pub. Date : 1998 May 7

PMID : 9620547






2 Functional Relationships(s)
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1 We found that binding of PtdIns4,5P2 to 6-his-tagged recombinant mSOS in vitro inhibits the ability of SOS to catalyze the association of GTP on p21RAS. Guanosine Triphosphate xylosyltransferase 2 Homo sapiens
2 In addition, the inhibition of Ras GTP-binding is not blocked by excess free inositols suggesting that SOS binds to PtdIns4,5P2 with higher affinity than it binds to free inositols. Guanosine Triphosphate xylosyltransferase 2 Homo sapiens