Title : Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation.

Pub. Date : 1998 May 7

PMID : 9620546






1 Functional Relationships(s)
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1 In MEN2A mutations affecting cysteine residues in the extracellular domain of the receptor cause constitutive activation of the tyrosine kinase by the formation of disulfide-bonded homodimers. Cysteine ret proto-oncogene Homo sapiens