Title : p53 mutations in cyclophosphamide-associated bladder cancer.

Pub. Date : 1998 May

PMID : 9610789






3 Functional Relationships(s)
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1 p53 mutations in cyclophosphamide-associated bladder cancer. Cyclophosphamide tumor protein p53 Homo sapiens
2 We examined 19 cyclophosphamide-related bladder tumors to test the hypothesis that they might contain somatic mutations in the p53 tumor suppressor gene that could link a specific metabolite to the etiology of these cancers. Cyclophosphamide tumor protein p53 Homo sapiens
3 The p53 mutation spectrum of these cyclophosphamide-associated bladder cancers differed significantly from patterns reported for sporadic (P = 0.020), smoking-related (0.043), and schistosomiasis-linked (P = 0.002) tumors but not arylamine-associated neoplasms (P = 0.860). Cyclophosphamide tumor protein p53 Homo sapiens