Title : Cyclic nucleotide regulation of type-1 plasminogen activator-inhibitor mRNA stability in rat hepatoma cells. Identification of cis-acting sequences.

Pub. Date : 1998 Jun 5

PMID : 9603932






3 Functional Relationships(s)
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1 Incubation of HTC rat hepatoma cells with the cyclic nucleotide analogue, 8-bromo-cAMP, causes a dramatic increase in tissue-type plasminogen activator activity secondary to a 90% decrease in PAI-1 mRNA. 8-Bromo Cyclic Adenosine Monophosphate serpin family E member 1 Rattus norvegicus
2 Although 8-bromo-cAMP causes a modest decrease in PAI-1 transcription, regulation is primarily the result of a 3-fold increase in the rate of PAI-1 mRNA degradation. 8-Bromo Cyclic Adenosine Monophosphate serpin family E member 1 Rattus norvegicus
3 Although 8-bromo-cAMP causes a modest decrease in PAI-1 transcription, regulation is primarily the result of a 3-fold increase in the rate of PAI-1 mRNA degradation. 8-Bromo Cyclic Adenosine Monophosphate serpin family E member 1 Rattus norvegicus