Title : Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes.

Pub. Date : 1998 Jun

PMID : 9598563






5 Functional Relationships(s)
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1 PURPOSE: Sildenafil, an inhibitor of cGMP-specific phosphodiesterase 5 (PDE5), is currently undergoing evaluation as an oral therapy for penile erectile dysfunction. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
2 Compared with zaprinast, an early PDE5 inhibitor, sildenafil was approximately 240-fold more potent, inhibiting PDE5 from HCC with a geometric mean IC50 of 3.5 nM. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
3 Compared with zaprinast, an early PDE5 inhibitor, sildenafil was approximately 240-fold more potent, inhibiting PDE5 from HCC with a geometric mean IC50 of 3.5 nM. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
4 Sildenafil is a potent inhibitor of PDE5 from HCC, with high selectivity for PDE5 relative to other PDE isozymes. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
5 Sildenafil is a potent inhibitor of PDE5 from HCC, with high selectivity for PDE5 relative to other PDE isozymes. Sildenafil Citrate phosphodiesterase 5A Homo sapiens