Pub. Date : 1998
PMID : 9595512
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heparin suppresses cyclosporine-induced endothelin-1 synthesis in rat endothelial cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 2 | Cyclosporine stimulates vasoconstrictor endothelin-1 (ET-1) synthesis. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 3 | Cyclosporine stimulates vasoconstrictor endothelin-1 (ET-1) synthesis. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 4 | This study examined the effect of heparin on cyclosporine-induced ET-1 synthesis in Wistar rat aortic endothelial cells in culture. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 5 | Cyclosporine (0.01-5 mumol/L) stimulated ET-1 mRNA expression in a dose-dependent manner. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 6 | Heparin (1-20 U/ml) suppressed cyclosporine-induced ET-1 mRNA expression in a dose-dependent manner. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 7 | These results suggest that heparin suppresses cyclosporine-induced ET-1 mRNA expression via both NO- and calmodulin-dependent pathways. | Cyclosporine | endothelin 1 | Rattus norvegicus |