Pub. Date : 1998 May 20
PMID : 9593849
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 2 | The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 3 | The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 4 | The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates both the synthesis and phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho). | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 5 | In multidrug resistant MCF-7/MDR1 cells, which highly express PKC-alpha but lack the PtdCho-specific PLD activity, 100-nM PMA had relatively small stimulatory effects on the uptake of [14C]choline (approximately 1.5-fold) and [14C]PtdCho synthesis (1.5- to 2-fold). | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |
| 6 | In NIH 3T3 fibroblasts and MCF-7/PKC-alpha cells, both expressing PKC-alpha and PLD activities at high levels, 10-100-nM PMA enhanced [14C]choline uptake only slightly (1.7- to 2.2-fold), while it had much greater (approximately 4-9-fold) stimulatory effects on PtdCho synthesis. | Tetradecanoylphorbol Acetate | glycosylphosphatidylinositol specific phospholipase D1 | Homo sapiens |