Title : DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines.

Pub. Date : 1998 Jun 1

PMID : 9592149






3 Functional Relationships(s)
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1 We found that the lack of PARP renders cells significantly more sensitive to methylmethanesulfonate (MMS), causing cell growth retardation, G2/M accumulation and chromosome instability. Methyl Methanesulfonate poly (ADP-ribose) polymerase family, member 1 Mus musculus
2 We found that the lack of PARP renders cells significantly more sensitive to methylmethanesulfonate (MMS), causing cell growth retardation, G2/M accumulation and chromosome instability. Methyl Methanesulfonate poly (ADP-ribose) polymerase family, member 1 Mus musculus
3 Cell viability following MMS treatment could be fully restored after transient expression of the PARP gene. Methyl Methanesulfonate poly (ADP-ribose) polymerase family, member 1 Mus musculus