Pub. Date : 1998
PMID : 9585171
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metrifonate, a pro-drug that is transformed non-enzymatically into a potent inhibitor of acetylcholinesterase (AChE), has been used in the tropics for over 30 years for the treatment of schistosomiasis. | Trichlorfon | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Metrifonate, a pro-drug that is transformed non-enzymatically into a potent inhibitor of acetylcholinesterase (AChE), has been used in the tropics for over 30 years for the treatment of schistosomiasis. | Trichlorfon | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | A pilot study, and Phase I and Phase II studies of metrifonate in Alzheimer"s disease (AD) patients conducted prior to the current study showed benign, dose-dependent adverse event profiles consisting primarily of gastrointestinal events, optimal daily dosing with a loading phase (in the absence of a loading dose phase, 6-8 weeks were required to attain steady-state AChE inhibition levels), and an improvement in Alzheimer"s Disease Assessment Scale (ADAS) scores. | Trichlorfon | acetylcholinesterase (Cartwright blood group) | Homo sapiens |