Pub. Date : 1998
PMID : 9585152
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We compared the effects of azelastine, an anti-allergic drug, on TNF-alpha secretion, on Ca2+ signal, and on degranulation in an antigen- or ionomycin-stimulated rat mast RBL-2H3 cell line. | azelastine | tumor necrosis factor | Rattus norvegicus |
| 2 | Azelastine inhibited TNF-alpha release at concentrations lower than those needed for the inhibition of degranulation. | azelastine | tumor necrosis factor | Rattus norvegicus |
| 3 | In antigen-stimulated cells, azelastine also inhibited equipotently TNF-alpha mRNA expression/protein synthesis, TNF-alpha release and Ca2+ influx. | azelastine | tumor necrosis factor | Rattus norvegicus |
| 4 | In antigen-stimulated cells, azelastine also inhibited equipotently TNF-alpha mRNA expression/protein synthesis, TNF-alpha release and Ca2+ influx. | azelastine | tumor necrosis factor | Rattus norvegicus |
| 5 | In ionomycin-stimulated cells, however, azelastine inhibited TNF-alpha release to a greater extent than TNF-alpha mRNA expression/protein synthesis and Ca2+ influx, indicating that azelastine inhibits the release process more potently than transcription or production of TNF-alpha by interfering with a signal other than Ca2+. | azelastine | tumor necrosis factor | Rattus norvegicus |