Title : Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis.

Pub. Date : 1998 Mar

PMID : 9583368






3 Functional Relationships(s)
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1 Glutamine-supplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Glutamine C-X-C motif chemokine ligand 8 Homo sapiens
2 Glutamine supplementation did not significantly influence TNF or IL-6 release, but, in contrast, median IL-8 release was reduced by day 7 in the glutamine group while it was increased in the conventional group (-17.7 ng/mL (median change over study period) versus +43.3 ng/mL, respectively; P=0.045). Glutamine C-X-C motif chemokine ligand 8 Homo sapiens
3 Small patient numbers and substantial interindividual variation limit the conclusions, but there is a trend for the glutamine group to have improved lymphocyte proliferation, and in the case of IL-8, reduced proinflammatory cytokine release. Glutamine C-X-C motif chemokine ligand 8 Homo sapiens