Pub. Date : 1998 Apr 2
PMID : 9582014
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 2 | Further, the inhibition of melanogenesis by TPA results from a decrease of the tyrosinase promoter transcriptional activity and this effect is mimicked by over-expression of a constitutively active form of PKC alpha. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 3 | Additional experiments were undertaken to elucidate the mechanism by which TPA inhibits the tyrosinase gene transcription. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 4 | Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 5 | Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 6 | Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |
| 7 | Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition. | Tetradecanoylphorbol Acetate | tyrosinase | Mus musculus |