Pub. Date : 1998 May 1
PMID : 9581833
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By analyzing the effect of PRL on IFN alpha/beta-induced tyrosine phosphorylation of Stat proteins and their binding to IFN-regulated genes, we now report that costimulation of PRL receptors did not interfere with IFN alpha/beta signals in several human breast cancer cell lines, including T47D, MCF-7, and BT-20. | Tyrosine | interferon alpha 1 | Homo sapiens |
| 2 | By analyzing the effect of PRL on IFN alpha/beta-induced tyrosine phosphorylation of Stat proteins and their binding to IFN-regulated genes, we now report that costimulation of PRL receptors did not interfere with IFN alpha/beta signals in several human breast cancer cell lines, including T47D, MCF-7, and BT-20. | Tyrosine | interferon alpha 1 | Homo sapiens |
| 3 | Instead, IFN alpha/beta- and PRL-induced tyrosine phosphorylation of Stat1 was additive and occurred without evidence of competition for limited concentrations of cytoplasmic Stat1. | Tyrosine | interferon alpha 1 | Homo sapiens |
| 4 | A similar additive relationship was observed on IFN alpha/beta- and PRL-induced Stat3 tyrosine phosphorylation. | Tyrosine | interferon alpha 1 | Homo sapiens |