Title : The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.

Pub. Date : 1998 May 1

PMID : 9581827






1 Functional Relationships(s)
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1 In this report, we compared and contrasted the pharmacology of raloxifene to block or induce E2-stimulated increase in TGF-alpha mRNA in stable transfectants of ER-negative human breast cancer cells with the cDNAs from wild-type, mutant-amino acid (AA) 400 ER and mutant-AA 351 ER. Raloxifene Hydrochloride transforming growth factor alpha Homo sapiens