Title : Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets.

Pub. Date : 1998 Apr

PMID : 9579743






1 Functional Relationships(s)
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1 In whole platelets, indomethacin reduced the increase in cyclic GMP induced by the nitric oxide-donors (NO-donors) sodium nitroprusside (NaNP) and S-nitroso-N-acetylpenicillamine (SNAP) in a dose-dependent way, its IC50 being 13.7 microM and 15.8 microM, respectively. S-Nitroso-N-Acetylpenicillamine 5'-nucleotidase, cytosolic II Homo sapiens