Title : Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium.

Pub. Date : 1998 May 15

PMID : 9575150






4 Functional Relationships(s)
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1 Expression of the receptor tyrosine kinase Ret on the plasma membrane is dependent on calcium. Calcium ret proto-oncogene Homo sapiens
2 Here we show that expression of p170(ret) is dependent on calcium. Calcium ret proto-oncogene Homo sapiens
3 Depletion of extracellular calcium completely blocks p170(ret) expression, which is not caused by a decrease in half-life of p170(ret) at the plasma membrane but by a defect in processing of p150(ret) into p170(ret). Calcium ret proto-oncogene Homo sapiens
4 We propose that a relatively high concentration of luminal calcium is necessary for the proper folding of Ret in the endoplasmic reticulum. Calcium ret proto-oncogene Homo sapiens