Pub. Date : 1998 Feb
PMID : 9574865
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A possible role for protein kinase C in CO2/H+-induced c-fos mRNA expression in PC12 cells. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | In the present studies we examined the role of protein kinase C (PKC) pathway in CO2-induced c-fos expression. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | Depletion of PKC abolished the effect of CO2 on c-fos mRNA expression, inhibited MAP kinases tyrosine phosphorylation and suppressed the expression of PKC(alpha) and PKC(zeta). | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | These results suggest that MAP kinases, PKC(alpha) and/or PKC(beta) might be involved in CO2-induced c-fos mRNA expression. | N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |