Title : c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase.

Pub. Date : 1998 May 8

PMID : 9565618






1 Functional Relationships(s)
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1 We have shown that osteopontin binding to integrin alphav beta3 in osteoclasts stimulates gelsolin-associated phosphatidylinositol (PtdIns) 3-hydroxyl kinase (PI 3-kinase), leading to increased levels of gelsolin-bound PtdIns 3,4-P2, PtdIns 4,5-P2, and PtdIns 3, 4,5-P3, uncapping of barbed end actin, and actin filament formation. Phosphatidylinositols gelsolin Homo sapiens