Pub. Date : 1998 May 1
PMID : 9556569
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). | Heparin | interferon gamma | Homo sapiens |
| 2 | Interferon-gamma (IFNgamma), in common with a number of growth factors, binds both to heparan sulfate or heparin-related molecules and to a specific high affinity receptor (IFNgammaR). | Heparin | interferon gamma | Homo sapiens |
| 3 | This binding assay was used to investigate a possible role of heparin in the IFNgamma.IFNgammaR complex formation. | Heparin | interferon gamma | Homo sapiens |
| 4 | In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. | Heparin | interferon gamma | Homo sapiens |
| 5 | In contrast to growth factors for which binding to heparin is usually required for high affinity receptor interaction, we found in this study that IFNgamma bound to heparin displayed a strongly reduced affinity for its receptor. | Heparin | interferon gamma | Homo sapiens |
| 6 | To understand how a single domain of IFNgamma could be implicated in two discrete functions (i.e. binding to heparin and to IFNgammaR), we also analyzed in a detailed manner the role of the IFNgamma carboxyl-terminal sequence in receptor binding. | Heparin | interferon gamma | Homo sapiens |
| 7 | Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. | Heparin | interferon gamma | Homo sapiens |
| 8 | Using forms of IFNgamma, with carboxyl terminus truncations of defined regions of the heparin binding sequence, we found that the C1 domain functioned by increasing the on rate of the IFNgamma.IFNgammaR binding reaction but was not otherwise required for the stability of the complex. | Heparin | interferon gamma | Homo sapiens |