Title : Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis.

Pub. Date : 1998 Apr 24

PMID : 9553056






1 Functional Relationships(s)
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1 This cytoskeletal response is rapid, peaking 2 h after thrombin stimulation, and reverses by 50% after 24 h. The thrombin receptor peptide SFLLRNP also induces cell rounding, whereas other G protein-linked receptor agonists such as carbachol, lysophosphatidic acid, or bradykinin fail to do so. lysophosphatidic acid coagulation factor II, thrombin Homo sapiens