Title : Cleavage of membrane-associated ICAM-1 from astrocytes: involvement of a metalloprotease.

Pub. Date : 1998 Feb

PMID : 9537830






1 Functional Relationships(s)
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1 The half-life of TNF-alpha induced membrane-associated ICAM-1 on rat astrocytes is approximately 5 h. The proteolytic cleavage process for the conversion of membrane-associated ICAM-1 to sICAM-1 was sensitive to Batimastat (BB94) and phosphoramidon, two inhibitors of metalloproteases, whereas inhibitors of serine-, cysteine-, aspartic-, and chymotrypsin-like proteases had no effect on this process. phosphoramidon tumor necrosis factor Rattus norvegicus