Title : Cyanide-induced generation of oxidative species: involvement of nitric oxide synthase and cyclooxygenase-2.

Pub. Date : 1998 Apr

PMID : 9536016






2 Functional Relationships(s)
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1 Using selective enzyme inhibitors, it was shown that both protein kinase C and phospholipase A2 are involved in KCN-stimulated generation of NO and ROS. Potassium Cyanide phospholipase A2 group IB Homo sapiens
2 Pretreatment with inhibitors of protein kinase C, phospholipase A2 or COX, LOX, COX-2 partially blocked KCN-induced formation of thiobarbituric acid reactive substance, whereas coincubation of L-NAME with the inhibitors decreased lipid peroxidation by 60 to 90%. Potassium Cyanide phospholipase A2 group IB Homo sapiens