Title : Evidence that gonadotropin-releasing hormone stimulates gene expression and levels of active nitric oxide synthase type I in pituitary gonadotrophs, a process altered by desensitization and, indirectly, by gonadal steroids.

Pub. Date : 1998 Apr

PMID : 9529006






4 Functional Relationships(s)
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1 Testosterone or estradiol replacement, or administration of GnRH antagonist, totally abolished the effects of castration, demonstrating a mediation of the steroid effects via GnRH. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
2 Testosterone or estradiol replacement, or administration of GnRH antagonist, totally abolished the effects of castration, demonstrating a mediation of the steroid effects via GnRH. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
3 In noncastrated rats, steroids and the GnRH antagonist also caused a reduction in the levels of NOS I (by 50-60%), consistent with inhibition of endogenous GnRH stimulation. Steroids gonadotropin releasing hormone 1 Rattus norvegicus
4 Taken together, these data demonstrate that steroids indirectly regulate NOS I messenger RNA and protein levels, through the hypothalamic modulation of GnRH, which represents the primary regulator of NOS I. Steroids gonadotropin releasing hormone 1 Rattus norvegicus