Pub. Date : 1998 Apr 3
PMID : 9525968
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 2 | The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 3 | One of the major unsolved problems in xenobiotic metabolism is the molecular mechanism whereby phenobarbital induces hepatic enzymes, particularly CYP2B1 and CYP2B2 in rat liver. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 4 | By using primary rat hepatocytes for transfection analyses, we previously identified in the CYP2B2 5"-flank a 163-base pair Sau3AI fragment that confers phenobarbital inducibility on a cat reporter gene and that has the properties of a transcriptional enhancer. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 5 | Taken together, the results indicate that phenobarbital induction of CYP2B2 requires interactions among multiple regulatory proteins and cis-acting elements constituting a phenobarbital response unit. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |
| 6 | Taken together, the results indicate that phenobarbital induction of CYP2B2 requires interactions among multiple regulatory proteins and cis-acting elements constituting a phenobarbital response unit. | Phenobarbital | cytochrome P450, family 2, subfamily b, polypeptide 2 | Rattus norvegicus |