Pub. Date : 1998 Mar 20
PMID : 9507015
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Requirements of focal adhesions and calcium fluxes for interleukin-1-induced ERK kinase activation and c-fos expression in fibroblasts. | Calcium | interleukin 1 alpha | Homo sapiens |
| 2 | Previous studies in our laboratory showed that IL-1-induced calcium flux is dependent on focal adhesion formation, suggesting a matrix-dependent restriction system for IL-1 signaling. | Calcium | interleukin 1 alpha | Homo sapiens |
| 3 | Previous studies in our laboratory showed that IL-1-induced calcium flux is dependent on focal adhesion formation, suggesting a matrix-dependent restriction system for IL-1 signaling. | Calcium | interleukin 1 alpha | Homo sapiens |
| 4 | Plating cells on poly-L-lysine prevented focal adhesion formation, eliminated IL-1-induced calcium influx, abolished ERK stimulation, and blocked c-fos expression. | Calcium | interleukin 1 alpha | Homo sapiens |
| 5 | Calcium depletion abolished IL-1-induced calcium uptake, ERK activation, and c-fos expression. | Calcium | interleukin 1 alpha | Homo sapiens |
| 6 | Calcium depletion abolished IL-1-induced calcium uptake, ERK activation, and c-fos expression. | Calcium | interleukin 1 alpha | Homo sapiens |
| 7 | In transfection studies, IL-1 stimulation of serum responsive element (SRE) transcriptional activity was dependent on the presence of extracellular calcium. | Calcium | interleukin 1 alpha | Homo sapiens |
| 8 | Our results demonstrate that in cells attached to substrates by focal adhesions, IL-1-mediated calcium flux is required for ERK activation and c-fos expression but not for JNK or p38 activation. | Calcium | interleukin 1 alpha | Homo sapiens |