Title : Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.

Pub. Date : 1998 Mar 15

PMID : 9502784






2 Functional Relationships(s)
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1 Finally, the C609W HSCR mutation exerts a dual effect on RET since it leads to a decrease of the receptor at the cell surface and converted RET51 into a constitutively activated kinase due to the formation of disulfide-linked homodimers. Disulfides ret proto-oncogene Homo sapiens
2 Finally, the C609W HSCR mutation exerts a dual effect on RET since it leads to a decrease of the receptor at the cell surface and converted RET51 into a constitutively activated kinase due to the formation of disulfide-linked homodimers. Disulfides ret proto-oncogene Homo sapiens