Pub. Date : 1998 Mar 1
PMID : 9498792
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Post-translational processing of murine IL-1: evidence that ATP-induced release of IL-1 alpha and IL-1 beta occurs via a similar mechanism. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | Externalization and proteolytic processing of pro-IL-1 beta can be initiated by extracellular ATP. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | Proteolysis of pro-IL-1 beta initiates within 7.5 min of ATP addition; 17-kDa mature IL-1 beta is observed first intracellularly and subsequently extracellularly. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 4 | Macrophages exposed to ATP continuously or only for a 15-min pulse release IL-1 alpha, IL-1 beta, and lactate dehydrogenase (LDH). | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 5 | Ethacrynic acid and DIDS (4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid) block ATP-induced proteolysis of pro-IL-1 beta and prevent release of pro-IL-1 alpha/beta and LDH; they do not inhibit ATP-induced K+ (86Rb+) efflux. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 6 | These results indicate that ATP stimulates externalization of both IL-1 alpha and IL-1 beta. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |