Title : Time course of central nervous dopamine-D2 and 5-HT2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel) in patients with schizophrenia.

Pub. Date : 1998 Jan

PMID : 9497016






1 Functional Relationships(s)
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1 This could suggest that the combination of D2/5HT2 receptor blockade contributes to the antipsychotic effect and a low incidence of EPS seen with quetiapine in comparative phase three trials. Quetiapine Fumarate 5-hydroxytryptamine receptor 2A Homo sapiens