Title : Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis.

Pub. Date : 1998 Jan 15

PMID : 9492297






1 Functional Relationships(s)
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1 Using the lysosomotropic agent NH4Cl and the vesicularization inhibitor brefeldin A, we show here the convergence of TNF-alpha-induced death signaling on an acidic, subcellular compartment reminiscent of lysosomes. Ammonium Chloride tumor necrosis factor Homo sapiens