Pub. Date : 1998 Mar
PMID : 9492043
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. | Tyrosine | tumor protein p53 | Homo sapiens |
| 2 | Similarly, wild-type p53 decreased IGF-I-induced tyrosine phosphorylation of IRS-1. | Tyrosine | tumor protein p53 | Homo sapiens |
| 3 | In conclusion, p53 regulates IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I-induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line. | Tyrosine | tumor protein p53 | Homo sapiens |