Pub. Date : 1998 Mar
PMID : 9489720
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hippocampal slices exposed to various ROS and NO donors resulted in increases in levels of the active forms of both p42 MAPK and p44 MAPK. | Reactive Oxygen Species | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | The ROS- and NO-enhanced tyrosine phosphorylation and activation of p42 MAPK and p44 MAPK were inhibited by pretreatment with the antioxidant N-acetyl-L-cysteine. | Reactive Oxygen Species | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Our observations indicate that ROS and NO can mediate protein tyrosine phosphorylation and MAPK signaling in the hippocampus via a redox-sensitive mechanism and suggest a potential cellular mechanism for their effects in the nervous system. | Reactive Oxygen Species | mitogen-activated protein kinase 3 | Homo sapiens |