Pub. Date : 1998 Feb
PMID : 9488498
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of histamine and nitric oxide synthase inhibition on plasma levels of von Willebrand factor antigen. | Histamine | von Willebrand factor | Homo sapiens |
| 2 | Based on various studies in vitro, we hypothesized that the stimulatory action of histamine on vWf release could also be induced in vivo and that it may be inhibited by endogenous production of nitric oxide (NO). | Histamine | von Willebrand factor | Homo sapiens |
| 3 | Histamine caused an 11% (95% confidence interval (CI): 0.4% to 22%; p = 0.011) increase in vWf-Ag level at 125 minutes. | Histamine | von Willebrand factor | Homo sapiens |
| 4 | At 125 minutes, vWf-Ag level was significantly higher after either L-NMMA pretreatment when compared with the results after histamine alone (p < 0.05). | Histamine | von Willebrand factor | Homo sapiens |
| 5 | In conclusion, the infusion of histamine increased vWf-Ag level, and the inhibition of NO-synthase enhanced this effect, whereas it did not by itself elevate vWf-Ag level. | Histamine | von Willebrand factor | Homo sapiens |