Pub. Date : 1998 Feb 15
PMID : 9485023
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | Our studies were initiated by asking whether the translational product of the p53 gene is associated with cisplatin resistance in the 2780CP human ovarian tumor model. | Cisplatin | tumor protein p53 | Homo sapiens |
| 4 | We have demonstrated by single-strand conformation polymorphism analysis and sequencing that p53 in parental cisplatin-sensitive A2780 cells was wild type. | Cisplatin | tumor protein p53 | Homo sapiens |
| 5 | In parallel investigations using the Western technique, exposure of A2780 cells to clinically relevant concentrations of cisplatin (1-20 microM) resulted in time- and dose-dependent increases in p53, together with coordinate increases in p21Waf1/Cip1. | Cisplatin | tumor protein p53 | Homo sapiens |
| 6 | The results indicate that a defect exists in the signal transduction pathway for p53 induction following cisplatin-induced DNA damage in 2780CP cells, and this may represent a significant mechanism of cisplatin resistance. | Cisplatin | tumor protein p53 | Homo sapiens |
| 7 | The results indicate that a defect exists in the signal transduction pathway for p53 induction following cisplatin-induced DNA damage in 2780CP cells, and this may represent a significant mechanism of cisplatin resistance. | Cisplatin | tumor protein p53 | Homo sapiens |