Title : Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.

Pub. Date : 1998 Feb 19

PMID : 9484776






2 Functional Relationships(s)
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1 Keratinocytes from the HK1.bcl-2 mice were significantly more resistant to cell death induction by U.V.-B, DMBA, and TPA, compared to control keratinocytes. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene B cell leukemia/lymphoma 2 Mus musculus
2 Furthermore, papillomas developed at a significantly greater frequency and shorter latency in the HK1.bcl-2 mice compared to control littermates following initiation with DMBA and promotion with TPA. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene B cell leukemia/lymphoma 2 Mus musculus