Pub. Date : 1976 Aug
PMID : 948031
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of inhibitors of prostaglandin synthesis on venoconstrictor responses to bradykinin. | Prostaglandins | kininogen 1 | Canis lupus familiaris |
| 2 | The hypothesis that PGs mediate the venoconstrictor effect of bradykinin was evaluated by determining the influence of low concentrations of indomethacin (Indo) (1 muM) or eicosa-5,8,11,14-tetraynoic acid (ETA) (3 muM), two inhibitors of PG synthesis, on cumulative concentration-response curves for BK or norepinephrine (NE). | Prostaglandins | kininogen 1 | Canis lupus familiaris |
| 3 | The hypothesis that PGs mediate the venoconstrictor effect of bradykinin was evaluated by determining the influence of low concentrations of indomethacin (Indo) (1 muM) or eicosa-5,8,11,14-tetraynoic acid (ETA) (3 muM), two inhibitors of PG synthesis, on cumulative concentration-response curves for BK or norepinephrine (NE). | Prostaglandins | kininogen 1 | Canis lupus familiaris |
| 4 | These data suggest that endogenous PGs act to attenuate, rather than mediate, the venoconstrictor response to BK. | Prostaglandins | kininogen 1 | Canis lupus familiaris |
| 5 | However, these data do suggest that PGs are a determinant of venous responsiveness to BK. | Prostaglandins | kininogen 1 | Canis lupus familiaris |