Title : Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge.

Pub. Date : 1998 Jan

PMID : 9473635






3 Functional Relationships(s)
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1 MK801 abolished the increase in BDNF protein and trk B, but not trk C mRNA in granule cells at 4 h. These results demonstrate that MK801 differentially regulates the AD-increased expression of a group of genes previously identified as being likely candidates for an involvement in kindling. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus
2 MK801 abolished the increase in BDNF protein and trk B, but not trk C mRNA in granule cells at 4 h. These results demonstrate that MK801 differentially regulates the AD-increased expression of a group of genes previously identified as being likely candidates for an involvement in kindling. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus
3 Conversely, the role in kindling of those genes whose expression was significantly attenuated by MK801 (Fos, Jun-D, Krox-20, trkB and BDNF) requires further examination. Dizocilpine Maleate brain-derived neurotrophic factor Rattus norvegicus