Title : Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge.

Pub. Date : 1998 Jan

PMID : 9473635






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MK801 pretreatment produced a very strong inhibition of Fos, Jun-D and Krox-20 increases in dentate neurons but had a much smaller effect on Jun-B and c-Jun expression. Dizocilpine Maleate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Conversely, the role in kindling of those genes whose expression was significantly attenuated by MK801 (Fos, Jun-D, Krox-20, trkB and BDNF) requires further examination. Dizocilpine Maleate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus