Title : Inhibition of vaccinia virus replication by cyclosporin A analogues correlates with their affinity for cellular cyclophilins.

Pub. Date : 1998 Feb

PMID : 9472618






2 Functional Relationships(s)
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1 It was demonstrated that analogues with strong Cyp-binding activity, such as CsC, CsG and [MeAla6]CsA, also exhibit a strong antiviral effect. Cyclosporine peptidylprolyl isomerase G Homo sapiens
2 The data obtained suggest a correlation between the ability of CsA to block VV replication and Cyp binding activity, and indicate the involvement of Cyps in the VV replicative cycle. Cyclosporine peptidylprolyl isomerase G Homo sapiens