Pub. Date : 1997 Dec
PMID : 9468014
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the gonadotroph-derived alphaT3-1 cell line, PACAP acts via PVR1 receptors to stimulate adenylyl cyclase and phosphoinositidase C. PACAP-stimulated cAMP accumulation is inhibited by protein kinase C-activating phorbol esters in these cells and the current work was undertaken primarily to establish whether it is also subject to homologous regulation. | Cyclic AMP | adenylate cyclase activating polypeptide 1 | Mus musculus |
| 2 | In the gonadotroph-derived alphaT3-1 cell line, PACAP acts via PVR1 receptors to stimulate adenylyl cyclase and phosphoinositidase C. PACAP-stimulated cAMP accumulation is inhibited by protein kinase C-activating phorbol esters in these cells and the current work was undertaken primarily to establish whether it is also subject to homologous regulation. | Cyclic AMP | adenylate cyclase activating polypeptide 1 | Mus musculus |
| 3 | In chronic desensitization studies, pre-treatment for 6 h with PACAP27 caused a dose-dependent (IC50 approximately 10 nM) reduction of PACAP-stimulated cAMP accumulation and down regulated cell surface PVR1 receptors (to approximately 50%). | Cyclic AMP | adenylate cyclase activating polypeptide 1 | Mus musculus |
| 4 | Chronic desensitization of PACAP-stimulated cAMP accumulation and down-regulation of cell surface PVR-1 receptors also occurs in these cells although the receptor loss may not entirely explain the observed desensitization. | Cyclic AMP | adenylate cyclase activating polypeptide 1 | Mus musculus |